
Clinical Knowledgebase
JAX-Clinical Knowledgebase (CKB) is a powerful tool for interpreting complex genomic profiles, and represents a valuable resource for clinicians and translational and clinical researchers around the world.
Molecular profiling of tumors to identify mutations
that accumulate in cancer cells.
212 Gene panel (SNPs, CNVs and micro InDels):
ABL1, ABL2, AIM2, AKT1, AKT2, AKT3, ALK, APC, AR, ARAF, ARID1A, ATM, ATR, AURKA, AURKB, AXIN1, AXL, BAP1, BARD1, BCL2, BIRC5 (Survivin), BRAF, BRCA1, BRCA2, BRD3, BRD4, BRIP1, BTK, CALR, CBL, CCND1, CCND2, CCND3, CCNE1, CD274, CD79A, CD79B, CDK12, CDK4, CDK6, CDK8, CDKN1A, CDKN2A, CHEK1, CHEK2, CREBBP, CRKL, CSF1R, CSF3R, CTNNB1, CXCR4, DDR1, DDR2, DDX11, DNMT3A, DNMT3B, DYRK1B, EGFR, EP300, EPHA2, EPHB4, ERBB2, ERBB3, ERBB4, ERG, ESR1, ETV1, EZH1, EZH2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCL, FANCM, FBXW7, FES, FGF19, FGF3, FGFR1, FGFR2, FGFR3, FGFR4, FH, FLCN, FLT1, FLT3, FLT4, FRK, FRS2, GLI1, GLI2, GNA11, GNAQ, GNAS, GRM3, HGF, HRAS, HSP90AA1, ID1, ID2, ID3, IDH1, IDH2, IGF1R, IKBKE, IL7R, IRS2, JAK1, JAK2, JAK3, JUN, KDM4C, KDR, KEAP1, KIAA1524 (CIP2A), KIT, KRAS, LTK, MAP2K1, MAP2K2, MAP3K9, MAPK1, MCL1, MDM2, MDM4, MEN1, MET, MPL, MRE11 (MRE11A), MSH2, MSH6, MST1R (RON), MTOR, MYC, MYCL, MYCN, MYD88, NBN, NCOA3, NF1, NF2, NFE2L2, NISCH, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NRAS, NTRK1, NTRK2, NUAK2, PAK1, PALB2, PDGFRA, PDGFRB , PDPK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIM1, PLK1, POLB, POLR2A, PPARG, PPM1D, PPP2R1A, PPP2R1B, PRKAA1, PTCH1, PTEN, PTK2(FAK), PTPN11, PTPRB, RAD50, RAD51, RAD51C, RAD51D, RAF1, RARA, RB1, RET, RHEB, RICTOR, RIT1, RNF43, ROS1, RSPO2, RSPO3, SEM1 (SHFM1), SMARCB1, SMO, SRC, STAT3, STAT5A, STAT5B, STK11(LKB1), SYK, TGFBR2, TNK2 (ACK1), TP53, TP63, TSC1, TSC2, TTK (MPS1), VEGFA, VHL
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