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Jung-Bum Shin, Ph.D.

Assistant ProfessorUniversity of Virginia School of Medicine

We used a mass spectrometry-based approach to characterize the proteome of the mechanosensory
hair bundle of auditory and vestibular receptor cells, followed by characterization of novel deafness
candidate genes. The impact of this approach on hearing research is several fold:
- Identification of novel deafness genes: The proteomics-based approach lead to the identification
of 4 novel deafness genes so far (BCK, CLIC5, FSCN2, XIRP2)
- Molecular characterization of the hair bundle: the comprehensive characterization of the hair
bundle proteome provides a crucial compendium for a deeper understanding of processes
facilitating and integral to hair cell mechanotransduction
- To demonstrate in vivo relevance of the candidate genes, the CRISPR/Cas9 technology was
used to generate mouse models. Francis et al. (2015) is the first paper using the CRISPR
technology in hearing research
Sep 21 8:30 AM Wednesday, September 21, 2016 8:30am Lecture:  Hair Bundle Proteomics     
9:15am Lecture: Hair cells and mechanotransduction    
10:00am Coffee break    
10:15am Van shuttle to Research Lab    
10:30am 1.5 hour Teaching Lab workshop: begin dissections of cochlea and utricle in adults and neonates
12:00pm Lunch at Roscoe's    
1:00pm 5 hour Teaching Lab workshop(s)    continue dissections and cultures, paint fill demo
6:00pm    Van shuttle to Highseas    
6:30pm    Dinner at High Seas    
7:30pm Talk - Neuronal aspects of the inner ear    afferent and efferent innervation of the inner ear
8:15pm Talk - Neuronal aspects of the inner ear    CNS structures, cochlear nucleus, MNTB etc.