Michael R. Bowl, DPhil

Senior Investigator ScientistMRC Harwell Institute

Dr. Bowl is a Senior Investigator Scientist at the Mammalian Genetics Unit, MRC Harwell Institute, UK. He earned his BSc (Medical Biochemistry, 1998) and MPhil (Immunology and Oncology, 1999) from the University of Birmingham, and completed his DPhil (Molecular Endocrinology, 2003) at the University of Oxford, where he continued as a post-doctoral scientist until 2009. While at Oxford he was a Junior Research Fellow at Linacre College (2006-2008). Since 2010, Dr. Bowl has worked as a Team Leader at the MRC Harwell Institute where his research involves the identification of genes required for auditory function and the study of molecular processes underlying sensorineural hearing loss. To enable this, Dr. Bowl and his team employ phenotype- and gene-driven screens to identify novel mouse models of hearing loss. In particular, they utilize the Harwell Ageing Screen - the first large-scale mutagenesis screen designed to identify mouse models of age-related human disease, and the International Mouse Phenotyping Consortium (IMPC) – an international collaborative effort to generate and phenotype knockout mutants for every gene in the mouse genome. Using auditory screening, they are able to identify models for early- and late-onset hearing loss and, through characterization of these, discover novel genes and pathways required for normal hearing function. Ultimately, characterization of these models increases our knowledge of the genetic repertoire and molecular pathways required for mammalian hearing and will lead to the generation of strategies to ameliorate hearing loss or restore hearing function.

Sep 19 8:30 AM Monday, September 19, 2016 8:30am    Topic: Mouse genetics, nomenclature, and MGI
9:15am    Topic Genetic background and age-related effects
10:00am    Coffee break    
10:30am Topic: Microscopy in inner ear research
11:15am Lecture: New programs and resources, KOMP, resources for gene expression
12:00pm Lunch     
1:00pm Student poster presentations    
2:30pm Group photo    
2:45pm Van shuttle to Research Lab    
3:15pm Biomethods training    
4:30pm Jackson Lab tour     
5:00pm Visit Electron MIcroscopy Service and SEM demo      
6:00pm Van shuttle to Highseas    
6:30pm Dinner     
7:30pm New technologies: CRISPR-Cas genome editing
8:15pm New technologies: CRISPR-Cas applied to hearing research