Mak Tak

Tak W. Mak, Ph.D.

Senior Scientist, Princess Margaret Cancer CentreUniversity Health Network

Dr. Tak Mak iinternationally knowfor his work ithe molecular biology of cancer and the immune systemHis a Professor in the Department of Medical Biophysicand the Department of Immunology at the University of Toronto; the Director of the Campbell FamilInstitute for BreasCancer Researcat the Princess Margaret Cancer Centre; Senior Scientist at the Ontario Cancer Institute and Professor, University of Hong Kong.


Dr. Mak is a world leader ithe genetics of immunology and cancerIn 1984, he led thgroup that discovered the T cell receptor, and his published work on the cloning of T cell antigen receptor genes has been cited over 1,400 times. Since this landmark discoveryDr. Mak has focused on elucidating the mechanisms underlying immune responses and tumorigenesis. He pioneered the use of genetically engineered mouse strains tidentify genetic susceptibility factorassociated witvarious immune disorders or different types of cancer. In particular, hiteam discovered thatCTLA4 is a negativregulator of T cell activatio(cited 3,000 times), paving the way for the development of anti-CTLA4 agents now iclinical use for autoimmune diseases. Dr. Maks lab also made major contributions to defining the functions of PTEN (cited >3,000 times) as well as threlationshibetween the breast cancer susceptibility genes BRCA1 and BRCA2 and defectiDNA repair. Most recentlyDr. Makstudies of the functions of variougene products in normal and canceroucellaryielding important information on their biology that icrucial for theidentification of new drug targetand the development of more effective cancer therapies.


Recognitions include:

Officer of the Ordeof Canada

Gairdner Foundation International Award (Canada)

Foreign Associate of the National Academy of Science(USA) Fellow of the RoyaSociety (Canada)

Fellow of the RoyaSociety (U.K.)

King Faisal Prize for Medicine (Saudi ArabiaSloan Prize of the GM CanceFoundation (USA)

Paul Ehrlich and Ludwig Darmstaedter Prize (Germany)

Medicine Doctor HonoriCausa, Karolinska Institutet, Stockholm, Sweden

Signal Transduction Society/Cell Communication and Signaling (STS/CCS) Honorary Medal 2016