Steve Brown, Ph.D.
ProfessorUniversity of Zurich
After undergraduate research in yeast genetics and graduate studies on chromatin biochemistry at Harvard, I moved to Geneva for postdoctoral work, where I first studied biological clocks and sleep in the laboratory of Ueli Schibler. After a stay at Charité Universitätsmedezin as a Humboldt fellow, I returned to Switzerland in 2007 as an assistant professor and then professor. My laboratory studies the molecular mechanisms and neural circuits underlying sleep and diurnal behaviour, using human cells and mouse models. Our studies of human cells recently culminated in cellular GWAS studies to show how common regulatory variation affects human daily behavior; and our mouse studies have led to the discovery of novel causes of human intellectual disability, and have shown how sleep and circadian influences cooperate to regulate synaptic dynamics. We have also pioneered the use of metabolomics to study circadian function, including in exhaled breath.