Amanda Lund, Ph.D.
Associate ProfessorOregon Health & Science University
Amanda W. Lund, PhD is an Associate Professor in the Ronald O. Perelman Department of Dermatology and Department of Pathology at the NYU Grossman School of Medicine and is a Member of the Laura and Isaac Perlmutter Cancer Center at NYU Langone Health. She received a PhD in Biology from Rensselaer Polytechnic Institute in Troy, New York (2009), and completed Postdoctoral training in cancer immunology with Dr. Melody A. Swartz at the Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland. Dr. Lund’s early work established the paradigm that tumor-associated lymphatic vessel remodeling plays a role in regulating anti-tumor immunity where lymphatic vessels are both necessary for adaptive immune priming and also contribute to multiple mechanisms of immune resolution and tumor immune escape. This work established the hypothesis that lymphatic vessels may be manipulated for improved response to immunotherapy. Dr. Lund’s lab is focused on understanding the underlying mechanisms that govern lymphatic/immune interactions in melanoma and skin. Her lab has identified new mechanisms of lymphatic vessel activation that drive context-dependent changes in adaptive immune responses through direct effects on endothelial activation and fluid and cellular transport. Elucidation of these specific molecular mechanisms is expected to lead to targeted interventions to tune lymphatic transport and impact immune responses against developing tumors either alone or in combination with existing immunotherapies.