Sheila Stewart, Ph.D.
ProfessorWashington University in St. Louis
Dr. Stewart is a Professor in the Department of Cell Biology and Physiology and Medicine at Washington University in St. Louis and is the Associate Director for Basic Science at the Siteman Cancer Center. Dr. Stewart has been the chair of AACR’s TME working group, a standing member of the NIH TME Study Section and reviews for the DOD, and ACS. She received her Ph.D. in Microbiology and Immunology from UCLA in 1997, and completed her postdoctoral fellowship in Cancer Biology at the Whitehead Institute at MIT in Robert Weinberg’s laboratory. Dr. Stewart is an American Cancer Society Scholar. Dr. Stewart’s research is focused on understanding how age-related changes in the tumor microenvironment impact tumorigenesis. Her laboratory has shown that aged stromal cells, similar to cancer associated fibroblasts express a plethora of pro-tumorigenic factors and has developed murine models to explore the role senescent stromal cells play in the preneoplastic and premetastatic niches. More recently she has begun to explore out some of these same changes contribute to therapy-induced comorbidities. In addition, the laboratory is examining how age-related changes in the premetastatic niche facilitate tumor cell seeding, dormancy and outgrowth and how these changes alter the local immune response to facilitate tumor cell proliferation.