Alan Shuldiner

Alan Rodney Shuldiner, M.D.

Vice PresidentRegeneron Genetics Center

Dr. Shuldiner received his undergraduate degree in chemistry from Lafayette College (Easton, PA; 1979), and his medical degree from Harvard Medical School (Boston, MA; 1984). He completed residency training in internal medicine at Columbia Presbyterian Hospital in New York, and his postdoctoral fellowship in Endocrinology and Metabolism in the Diabetes Branch at the National Institutes of Health in Bethesda. From 1991 to 1996, Dr. Shuldiner was a faculty member in the Division of Gerontology and Geriatric Medicine at Johns Hopkins University in Baltimore. From 1997-2014 he was a faculty member at the University of Maryland School of Medicine where he was the John Whitehurst Endowed Professor of Medicine, and served as Associate Dean and founding director of the Program for Genetics and Genomic Medicine, and Head of the Division of Endocrinology, Diabetes and Nutrition. Dr. Shuldiner’s major research interests lie in the molecular biology and genetics age-related diseases including of diabetes, obesity, osteoporosis, and cardiovascular disease, common disorders that contribute significantly to mortality, morbidity, and functional loss. He also works on the pharmaco- and nutri-genomics of these disorders. He is best known for his research in the Old Order Amish, a homogeneous founder population ideal for genetic studies. His multidisciplinary research team made several important genetic discoveries that have informed human biology and therapeutics including the first human null mutations in genes encoding apolipoprotein C-III (APOC3) and hormone sensitive lipase (LIPE), as well as discovery that common loss of function variants in CYP2C19 are major determinants of response to clopidogrel (Plavix) in coronary heart disease patients. In September 2014, Dr. Shuldiner became Vice President of the Regeneron Genetics Center where he continues to work in discovery and translational genomics, applying high-throughput sequencing and analytical approaches with academic collaborators throughout the world. Dr. Shuldiner has authored more than 400 original articles in leading journals and 70 reviews and book chapters. He is the recipient of a number of awards including the prestigious Paul Beeson Physician Faculty Scholar award, Ellison Medical Foundation Senior Scholar award, and 2006 University of Maryland Founders Day Researcher of the Year award. He has served on several steering and advisory committees and study sections related to his expertise in diabetes and related disorders, genomics, and translation of genetic discoveries to the clinical setting.