Matthew Hestand, PhD
Assistant Professor - Division of Human Genetics Cincinnati Children’s Hospital Medical Center
Breakthrough medical and biological discoveries can often be associated with technological advances. Therefore, to facilitate genomic discoveries Dr. Hestand has focused his career on cutting edge bioinformatics and DNA technologies. During his PhD in Leiden, the Netherlands, he performed both wet lab work and developed novel analyses methods for next-generation sequencing when it was in its infancy, already publishing on chromatin-immunoprecipitation sequencing (ChIP-seq) and next-generation tag based expression analyses in 2010. He then moved to the Gluck Equine Research Center where he contributed to refining the equine reference genome and annotation using whole genome resequencing and RNA-seq methods.
Since then, starting at the KU Leuven hospital in Belgium and continuing at the Cincinnati Children's Hospital Medical Center, he has used multiple state-of-the-art genomics technologies to gain a better understanding of nucleotide and structural variation in the complex repeat-rich region that causes the phenotypically diverse 22q11 deletion syndrome. Taking the next leap in sequencing technologies, he has also implemented long-read single-molecule sequencing for a multitude of basic and medical research applications. This recently culminated in two 2018 high impact review articles (in Nucleic Acids Research and Trends in Biotechnology) highlighting the breakthroughs in medical diagnostics by single-molecule sequencing.
At the Cincinnati Children's Hospital Medical Center, he continues to advance genomics medicine by streamlining and speeding up clinical bioinformatic analyses while implementing new and improved sequencing methods.