Recombinant inbred (RI) strains
Recombinant inbred (RI) strains are important resources for genetic mapping of both Mendelian and quantitative traits in the mouse. Individual RI strains generated from the same initial cross each have a unique combination of loci derived by recombination of the alleles present in the original parental strains. Since RI strains are inbred and each strain has a unique genotype, RI strains have a number of advantages over F2 or backcross mouse populations as tools for mapping genes or quantitative trait loci (QTL). In addition to the advantages, there are also limitations to the use of RI strains as currently configured.
Advantages
- Renewable resource - Unlike linkage cross progeny, a set of RI strains is a perpetually renewable resource since inbred strains are genetically stable.
- Data is cumulative & comparable - Genetic and phenotypic data acquired for an RI strain set are both cumulative and comparable, enhancing the value of the strain set for further studies. Phenotypic data can be collected in different laboratories, at different ages, and under different environmental conditions.
- Existing data means less work - Extensive genetic data and maps exist for most RI strain sets. Typically, no additional genotyping is necessary to map a newly characterized trait caused by loci that segregate in RI sets.
Limitations
- There are relatively few RI sets available from relatively few inbred strains.
- The size of current RI panels is relatively small - Most RI panels typically consist of fewer than 30 lines. This limits the power and precision of mapping quantitative trait loci.
Generation of RI Strains
The standard method to produce RI strains is to cross Strain A and Strain B to give F1 progeny. The F1 mice are then crossed to produce an F2 generation. Randomly chosen F2 individuals are then continuously brother-sister mated for twenty or more generations when they are genetically fixed at more than 98% of the loci that differ between the two progenitor strains.
Individual RI strains generated from the same initial cross each have a unique combination of loci derived by recombination of the alleles present in the original parental strains.
AXB Recombinant Inbred Strains (16)
| Stock No. | Strain Name |
|---|---|
| 001673 | AXB1/PgnJ |
| 001674 | AXB2/PgnJ |
| 001676 | AXB4/PgnJ |
| 001677 | AXB5/PgnJ |
| 001678 | AXB6/PgnJ |
| 001679 | AXB8/PgnJ |
| 001681 | AXB10/PgnJ |
| 001683 | AXB12/PgnJ |
| 001826 | AXB13/PgnJ |
| 001684 | AXB13a/PgnJ |
| 001685 | AXB15/PgnJ |
| 001687 | AXB19/PgnJ |
| 001686 | AXB19a/PgnJ |
| 001688 | AXB19b/PgnJ |
| 001690 | AXB23/PgnJ |
| 001691 | AX24/PgnJ |
BXA Recombinant Inbred Strains (13)
| Stock No. | Strain Name |
| 001692 | BXA1/PgnJ |
| 001693 | BXA2/PgnJ |
| 001694 | BXA4/PgnJ |
| 001696 | BXA7/PgnJ |
| 001697 | BXA8/PgnJ |
| 001699 | BXA11/PgnJ |
| 001700 | BXA12/PgnJ |
| 001701 | BXA13/PgnJ |
| 001702 | BXA14/PgnJ |
| 001703 | BXA16/PgnJ |
| 001710 | BXA24/PgnJ |
| 001711 | BXA25/PgnJ |
| 001999 | BXA26/PgnJ |
BXD Recombinant Inbred Strains (53)
| Stock No. | Strain Name |
|---|---|
| 000036 | BXD1/TyJ |
| 000075 | BXD2/TyJ |
| 000037 | BXD5/TyJ |
| 000007 | BXD6/TyJ |
| 000084 | BXD8/TyJ |
| 000105 | BXD9/TyJ |
| 000012 | BXD11/TyJ |
| 000045 | BXD12/TyJ |
| 000040 | BXD13/TyJ |
| 000329 | BXD14/TyJ |
| 000095 | BXD15/TyJ |
| 000013 | BXD16/TyJ |
| 000015 | BXD18/TyJ |
| 000010 | BXD19/TyJ |
| 000330 | BXD20/TyJ |
| 000077 | BXD21/TyJ |
| 000043 | BXD22/TyJ |
| 000098 | BXD23/TyJ |
| 005243 | BXD24a/TyJ |
| 000031 | BXD24b/TyJ |
| 000081 | BXD25/TyJ |
| 006255 | BX25/TyJRwwJ |
| 000041 | BXD27/TyJ |
| 000047 | BXD28/TyJ |
| 000029 | BXD29/TyJ |
| 000083 | BXD31/TyJ |
| 000078 | BXD32/TyJ |
| 003222 | BXD33/TyJ |
| 003223 | BXD34/TyJ |
| 003225 | BXD36/TyJ |
| 003227 | BXD38/TyJ |
| 003228 | BXD39/TyJ |
| 003229 | BXD40/TyJ |
| 003230 | BXD42/TyJ |
| 007093 | BXD43/RwwJ |
| 007094 | BXD44/RwwJ |
| 007097 | BXD48/RwwJ |
| 007099 | BXD50/RwwJ |
| 007103 | BXD55/RwwJ |
| 007105 | BXD60/RwwJ |
| 007106 | BXD61/RwwJ |
| 007107 | BXD62/RwwJ |
| 007111 | BXD66/RwwJ |
| 007113 | BXD68/RwwJ |
| 007114 | BXD69/RwwJ |
| 007117 | BXD73/RwwJ |
| 007121 | BXD77/RwwJ |
| 007124 | BXD80/RwwJ |
| 007129 | BXD86/RwwJ |
| 007130 | BXD87/RwwJ |
| 007132 | BXD89/RwwJ |
| 007133 | BXD90/RwwJ |
| 007135 | BXD92/RwwJ |
| 007139 | BXD96/RwwJ |
| 007140 | BXD97/RwwJ |
| 007141 | BXD98/RwwJ |
| 007143 | BXD100/RwwJ |
BXH Recombinant Inbred Strains (13)
| Stock No. | Strain Name |
|---|---|
| 000008 | BXH9/TyJ |
| 000009 | BXH14/TyJ |
| 000011 | BXH4/TyJ |
| 000014 | BXH7/TyJ |
| 000032 | BX10/TyJ |
| 000033 | BX19/TyJ |
| 003784 | BX20/KccJ |
| 003786 | BX22/KccJ |
| 000034 | BXH2/TyJ |
| 000038 | BXH6/TyJ |
| 000039 | BXH11/TyJ |
| 000076 | BXH8/TyJ |
| 002632 | BXH2/Ty1BedJ |
CXB Recombinant Inbred Strains (13)
| Stock No. | Strain Name |
|---|---|
| 000351 | CXB1/ByJ |
| 000352 | CXB2/ByJ |
| 000353 | CXB3/ByJ |
| 000354 | CXB4/ByJ |
| 000355 | CXB5/ByJ |
| 000356 | CXB6/ByJ |
| 000357 | CXB7/ByJ |
| 001629 | CXB8/HiAJ |
| 001630 | CXB9/HiAJ |
| 001631 | CXB10/HiAJ |
| 001632 | CXB11/HiAJ |
| 001633 | CXB12/HiAJ |
| 001634 | CXB13/HiAJ |
