Special Mouse Strains Resource (SMSR) – Recombinant Inbred (RI) and Chromosome Substitution (CS) Strain panels
Many common inherited human diseases - such as diabetes, cardiovascular disease, obesity, autoimmune disease, and cancer - are genetically complex, resulting from the interaction of more than one gene. Advances in genetic methods and the completed sequencing of the human and mouse genomes make it feasible to detect, genetically map, and identify the genes underlying these complex disorders.
The SMSR is a resource of special strains of mice that are important tools for genetic analysis of such complex diseases. They include panels of recombinant inbred (RI) and chromosome substitution (CS) strains. The primary objective of this project is to make these highly valuable strains available to the scientific community and to enhance their value by additional characterization and curation. Examples are behavioral, reproductive, immunological, blood chemistries including lipds and electrolytes, and hematological studies in the C57BL/6J-Chr#A and C57BL/6J-Chr#PWD consomic panels. Collected phenotyping data is available at the Mouse Phenome Database website.
The SMSR is funded by a grant from the National Center for Research Resources and the Office of Research Infrastructure Programs (ORIP) of the National Institutes of Health (NIH Grant Number P40RR016049). Please reference this grant in citations acknowledging use of the resource.
