Genetics and Genomics

Our Research Focus

The ability to sequence and analyze entire mammalian genomes has created a revolution in biomedical research. Discovery has gone far beyond the single-gene sequence and protein function research previously possible. We are now investigating entire gene networks, background effects, the role of single nucleotide polymorphisms and structural variants across the genome, modeling genotype-phenotype relationships and much more.

Faculty & Staff

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Research Centers & Resources

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4D Nucleome Center

The ultimate goal of the JAX 4D Nucleome Center is to deliver a Nucleome Positioning System (NPS) for the generation of complex maps of chromatin interaction network in the...

DO-AS cohort data

Phenotype and RNAseq data from approx. 200 (B6-Col4a5 KO x DO)F1 mice

GFR Calculator

This tool calculates the glomerular filtration rate in mice using the FITC-inulin method

Mouse Models of Human Cancer Database (MMHCdb)

The Mouse Models of Human Cancer Database (formerly, the Mouse Tumor Biology database) integrates data on the frequency, incidence, genetics, and pathology of neoplastic...

Gene Ontology Consortium

The Gene Ontology (GO) project is a collaborative effort to address the need for consistent descriptions of gene products across databases.

Mouse Phenome Database

This resource is a collaborative standardized collection of measured data on laboratory mouse strains and populations. Includes baseline phenotype data sets as well as...

Digital Pathology Pipeline

Tools for automatic glomerulus identification and histological quantification from scanned PAS slides

FusorSV

FusorSV is a data mining-based framework that allows for comprehensive and robust detection of Structural Variations (SV) from next generation sequencing datasets. We built...

Mouse Genome Informatics

International database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data.

Voluntary Workplace Genomic Testing

Knockout Mouse Project (KOMP)

Scientists around the world are working to generate a targeted knockout mutation for every gene in the mouse genome through the Knockout Mouse...

Mouse Peroxisome Research Resource

The Mouse Peroxisome Research Resource (MPRR) at the Jackson Laboratory serves as a centralized resource for mouse models and monoclonal antibodies for basic and...

Mouse Mutant Resource

Mice harboring spontaneous mutations have long been a major source for animal models of human genetic disorders, particularly mendelian diseases. The Mouse Mutant Resource...

RFR-PEL

Random Forest Regression for Epigenetic Length prediction

QuIN

QuIN (Query tool for Interaction Networks, available at quin.jax.org) is a tool for visualizing, annotating, and querying chromatin interactions derived from technologies...

WORMHOLE

The WORM Human OrthoLogy Explorer is a meta-tool that uses machine learning to predict novel least diverged orthologs (LDOs) by integrating ortholog predictions from 17...

Upcoming Education

Online Courses and On-Demand Webinars