A new spontaneous mutation on Chromosome 17 in the mouse named head slant (hslt)
Leona Gagnon, Ken Bosom, and Ken Johnson
Source of Support:NIH/NCRR grant RR01183 and DC04301
Mutation (allele) symbol:hslt
Mutation (allele) name:head slant
Gene symbol:hslt
Strain of origin:SJL.Cg-Thy1a
Current strain name:SJL.Cg-Thy1a-hslt/J
Stock #003961 (view JAX® Mice Data Sheet for additional information including Price and Supply Information)
Phenotype categories:Head tilting, circling
Origin and Description:
Homozygous mutants display head tilting and some circling behavior indicating vestibular dysfunction.
Genetic Analysis
Mapping:This recessive mutation was mapped to Chr 17 by a linkage intercross with CAST/Ei. Analysis of 39 F2 progeny indicated that hslt is between markers D17Mit222 and D17Mit46, approximately 10 cM from the Chr 17 centromere. (Mapping results)
Allelism tests: A test for allelism with head-tilt (het), a similar mutation on proximal Chr 17 was negative. A mating between a het/het female and a hslt/+ male produced 16 progeny in two litters, all normal. A mating between a hslt/hslt female and a het/het male produced 31 progeny, all normal.
Pathology:
Whole mount of inner ears: mutant hslt/hslt compared with control littermate +/hslt. Otoconia of utricle/saccule appear to be missing.
ABR tests indicate mutants have normal hearing. Four mutants and six heterozygotes were tested, all had normal hearing.
Acknowledgements
We wish to acknowledge Jay Wellington for identification of the mutant, Sue Cook for colony establishment, and Kathy Pellieter for colony maintenance.
