What's new?
| We welcome your input about the phenotyping screens we are currently performing as well as any suggestions for screens you would like us to undertake in the future. |
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March 2007
Articles related to research in our facility are appearing regularly. Please read these articles to sample the results and efforts from our research - these are not formally cited:
Multiple Trait Measurements in 43 Inbred Mouse Strains Captures the Phenotypic Diversity Characteristic of Human Populations
Karen L Svenson, Randy Von Smith, Phyllis A Magnani, Heather R Suetin, Beverly Paigen, Jurgen K. Naggert, Renhua Li, Gary A. Churchill, and Luanne L Peters J Appl Physiol (February 22, 2007). doi:10.1152/japplphysiol.01077.2006
Functional Deficiency in IL-7 Caused by an N-Ethyl-N-nitrosourea-Induced Point Mutation
Jianxun Feng, Hongsheng Wang1 and Herbert C. Morse, III
2007 Genetics Society of America accepted for publication November 21, 2006
DOI: 10.1534/genetics.106.066043
Cardiovascular phenotyping of fetal mice by noninvasive high-frequency ultrasound facilitates recovery of ENU-induced mutations causing congenital
cardiac and extracardiac defects
Yuan Shen, L. Leatherbury, J. Rosenthal, Qing Yu, M. A. Pappas, A. Wessels, J.
Lucas, B. Siegfried, B. Chatterjee, Karen Svenson and C. W. Lo
Physiol Genomics 24:23-36, 2005 doi:10.1152/physiolgenomics.00129.2005
First publishedSep 20, 2005;
ENU induced mutations causing congenital cardiovascular anomalies
Qing Yu, Yuan Shen, Bishwanath Chatterjee, Brett H. Siegfried, Linda Leatherbury, Julie Rosenthal, John F. Lucas, Andy Wessels, Chris F. Spurney, Ying-Jie Wu, Margaret L. Kirby, Karen Svenson and Cecilia W. Lo Development 131, 6211-6223
Published by The Company of Biologists 2004
doi:10.1242/dev.01543
January 2007
See our updated mapped mutant matrix - This matrix will continue to be updated as we complete mapping on heritable lines.
Removed as Not Heritable: 405; 453; 484; 485; 487
Removed as Non-Productive: 80; 147; 230
See the files from our 2006 workshop here.
May 2006
See our new mapped mutant matrix - This matrix will continue to be updated as we complete mapping on heritable lines.
Please visit our 'Available Now' webpage, as we have many phenotypes of heritable trait breeding pairs or cryopreserved lines available for heart, lung, blood and sleep researchers.
The following phenotypic deviants were posted during the month of May, 2006:
| Phenotype Index: | HLB Number(s): |
| Tachycardia | 468 |
| Obesity | 349A |
| ECG - Long QT | 424 |
| ECG - Long QT and Prolonged QTC interval | 432 |
| ECG - Tachycardia | 459 |
| High HDL | 476 |
| High HDL | 500 |
April 2006
Removal of some lines from development- In order to concentrate resources on the most productive phenotypic models we have ceased development of a few lines, and have removed them from heritability breeding. For more information on our current lines please visit our list of models in development, and our available now mutant list.
March 2006
3/2/06 NOCI0602 no longer available - These mice are removed.
February 2006
2/1/06 NOCI animals available - The following mice are available to researchers on a first come, first served basis. These animals are Not of Central Interest (NOCI) to our mutagenesis screen. These mice are being offered on a first come, first served basis for 30 days from the date of the posting - 2/1/06.
NOCI0602 - Coat color deviant - 1 affected male and three unaffected female siblings.
Workshop notice - We will be offering a new workshop combining features from previously popular phenotyping and microarray analysis workshops. The new educational opportunity is titled "Integrative Approaches to the Analysis of Heart, Lung, Blood and Sleep Disorders", and will happen Apr 23, 2006 - Apr 28, 2006 at The Jackson Laboratory.
January 2006
Workshop notice - We will be offering a new workshop combining features from previously popular phenotyping and microarray analysis workshops. The new educational opportunity is titled "Integrative Approaches to the Analysis of Heart, Lung, Blood and Sleep Disorders", and will happen Apr 23, 2006 - Apr 28, 2006 at The Jackson Laboratory.
Update 1/30/06 - These animals have been requested, and are no longer available. - The following mice are available to researchers on a first come, first served basis. These animals are Not of Central Interest (NOCI) to our mutagenesis screen. These mice are being offered on a first come, first served basis for 30 days from the date of the posting
NOCI0601 - Abnormal coloration
Program for Genomic Applications (PGA)
Supported by the National Heart, Lung, and Blood Institute (NHLBI) (Grant # HL66611)
