The Cytogenetic Models Resource
The Cytogenetic Resource is funded by an NICHD/NIH contract; first time users are required to fill out a request form for mice. Please complete and submit the request form to NIH. Your order must be placed with our Customer Service Department at 1-800-422-MICE or (207) 288-5845, or fax to 207-288-6150.
The Jackson Laboratory Cytogenetic Models Resource maintains and distributes chromosome aberration stocks that provide primarily mouse models for Down syndrome. Human Chromosome (Chr) 21 is trisomic in Down syndrome. Many human Chr 21 genes are conserved in mouse Chr 16. The Resource currently provides two models for Down syndrome research: (1) Rb(6.16)24Lub x Rb(16.17)7Bnr F1 hybrids that are used to produce Chr 16 trisomy (Ts16) embryos, which have many of the fetal developmental features of DS; (2) Ts(1716)65Dn, segmental trisomy mice that survive to adulthood and have many of the features of DS. Ts65Dn mice are trisomic for most of the human Chr 21-homologous genes in the distal segment of mouse Chr 16. The Resource also includes stocks with selected reciprocal translocations involving Chr 16 and some Chr 16 transgenic stocks. In addition, a large number of Robertsonian chromosome stocks are held as frozen embryos in the Cryopreservation Resource. Each mouse chromosome is present in at least two different Robertsonian chromosomes in these strains so that specific trisomies for each of the 19 mouse autosomes can be produced. This is the most extensive collection of Robertsonian chromosome mice in the United States. Breeding pairs and individual mice are provided.
Anyone wishing to obtain information on any of the strains may email Muriel T. Davisson
Cytogenetic Models Resource Project Director: Cathleen Lutz, Ph.D.
This Resource is supported by NICHD/NIH contract # N01-HD-73265. Please reference this funding in citations acknowledging use of the resource.
