Bibliography
2007
Aldridge K, Reeves RH, Olson LE, Richtsmeier JT. (2007). Differential effects of trisomy on brain shape and volume in related aneuploid mouse models. Am J Med Genet A. 143(10):1060-70. PMID: 17431903
Arriagada C, Astorga C, Atwater I, Rojas E, Mears D, Caviedes R, Caviedes P. (2007). "Endosomal abnormalities related to amyloid precursor protein in cholesterol treated cerebral cortex neuronal cells derived from trisomy 16 mice, an animal model of Down syndrome."Neurosci Lett. 423(2):172-7. PMID: 17706358
Bambrick LL, Fiskum G. (2007). "Mitochondrial dysfunction in mouse trisomy 16 brain. Brain Res. 2007 Oct 26; [Epub ahead of print] PMID: 18061151
Belichenko PV, Kleschevnikov AM, Salehi A, Epstein CJ, Mobley WC. (2007). "Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships."J Comp Neurol. 504(4):329-45. PMID:
Best TK, Siarey RJ, Galdzicki Z. (2007). "Ts65Dn, a mouse model of Down syndrome, exhibits increased GABAB-induced potassium current."J Neurophysiol. 97(1):892-900. PMID: 17093127
Chakrabarti L, Galdzicki Z, Haydar TF. (2007). "Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome."J Neurosci. 27(43):11483-95. PMID: 17959791
Chang Q, Gold PE. (2008). "Age-related changes in memory and in acetylcholine functions in the hippocampus in the Ts65Dn mouse, a model of Down syndrome." Neurobiol Learn Mem. 2008 89(2):167-77. PMID: 17644430
Contestabile A, Fila T, Ceccarelli C, Bonasoni P, Bonapace L, Santini D, Bartesaghi R, Ciani E. (2007). "Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with Down syndrome and in Ts65Dn mice."Hippocampus. 17(8):665-78. PMID: 17546680
Davisson M, Akeson E, Schmidt C, Harris B, Farley J, Handel MA. (2007). "Impact of trisomy on fertility and meiosis in male mice."Hum Reprod. 2007 22(2):468-76. PMID: 17050550
Dowjat WK, Adayev T, Kuchna I, Nowicki K, Palminiello S, Hwang YW, Wegiel J. (2007). "Trisomy-driven overexpression of DYRK1A kinase in the brain of subjects with Down syndrome."Neurosci Lett. 2007 413(1):77-81. PMID: 1714513
Fernandez F, Garner CC. (2007). "Object recognition memory is conserved in Ts1Cje, a mouse model of Down syndrome."Neurosci Lett. 421(2):137-41. PMID: 1756665
Hanson JE, Blank M, Valenzuela RA, Garner CC, Madison DV. (2007). "The functional nature of synaptic circuitry is altered in area CA3 of the hippocampus in a mouse model of Down's syndrome."J Physiol. 579(Pt 1):53-67. PMID: 1715817
Hill CA, Reeves RH, Richtsmeier JT. (2007). "Effects of aneuploidy on skull growth in a mouse model of Down syndrome."J Anat. 210(4):394-405. PMID: 17428201
Kirsammer G, Jilani S, Liu H, Davis E, Gurbuxani S, Le Beau MM, Crispino JD. (2007). "Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome."Blood. 2007 Sep 27; [Epub ahead of print] PMID: 1790124
Li Z, Yu T, Morishima M, Pao A, LaDuca J, Conroy J, Nowak N, Matsui S, Shiraishi I, Yu YE. (2007). "Duplication of the entire 22.9 Mb human chromosome 21 syntenic region on mouse chromosome 16 causes cardiovascular and gastrointestinal abnormalities."Hum Mol Genet. 16(11):1359-66. PMID: 17412756
Moore CS, Roper RJ. (2007). "The power of comparative and developmental studies for mouse models of Down syndrome."Mamm Genome. 18(6-7):431-43. Review. PMID: 17653795
Olson LE, Roper RJ, Sengstaken CL, Peterson EA, Aquino V, Galdzicki Z, Siarey R, Pletnikov M, Moran TH, Reeves RH. (2007). "Trisomy for the Down syndrome 'critical region' is necessary but not sufficient for brain phenotypes of trisomic mice."Hum Mol Genet. 16(7):774-82. PMID: 17339268
Parsons T, Ryan TM, Reeves RH, Richtsmeier JT. (2007). "Microstructure of trabecular bone in a mouse model for Down syndrome."Anat Rec (Hoboken). 290(4):414-21. PMID: 17514765
Rojas G, Càrdenas AM, Fernàndez-Olivares P, Shimahara T, Segura-Aguilar J, Caviedes R, Caviedes P. (2007). "Effect of the knockdown of amyloid precursor protein on intracellular calcium increases in a neuronal cell line derived from the cerebral cortex of a trisomy 16 mouse."Exp Neurol. 2007 Oct 5; [Epub ahead of print] PMID: 17976585
Salehi A, Faizi M, Belichenko PV, Mobley WC. (2007). "Using mouse models to explore genotype-phenotype relationship in Down syndrome."Ment Retard Dev Disabil Res Rev. 13(3):207-14. PMID: 17910089
Stewart LS, Persinger MA, Cortez MA, Snead OC 3rd. (2007). "Chronobiometry of behavioral activity in the Ts65Dn model of Down syndrome."Behav Genet. 37(2):388-98. PMID: 17146725
Sultan M, Piccini I, Balzereit D, Herwig R, Saran NG, Lehrach H, Reeves RH, Yaspo ML.(2007). "Gene expression variation in Down's syndrome mice allows prioritization of candidate genes."Genome Biol. 8(5):R91. PMID:
2006
Caviedes P, Caviedes R, Rapoport SI. (2006). ÒAltered calcium currents in cultured sensory neurons of normal and trisomy 16 mouse fetuses, an animal model for human trisomy 21 (Down syndrome). Biol Res. 39(3): 471-81. PMID: 17106579
Clark, S., J. Schwalbe, et al. (2006). "Fluoxetine rescues deficient neurogenesis in hippocampus of the Ts65Dn mouse model for Down syndrome." Exp Neurol. PMID: 16624293
Contestabile, A., T. Fila, et al. (2006). "Choline acetyltransferase activity at different ages in brain of Ts65Dn mice, an animal model for Down's syndrome and related neurodegenerative diseases." J Neurochem 97(2): 515-26. PMID: 16539660
Delabar JM, Aflalo-Rattenbac R, CrŽau N. (2006). ÒDevelopmental defects in trisomy 21 and mouse models.Ó Scientific World Journal. 6: 1945-64. PMID: 17205199
Dorsey, S. G., C. L. Renn, et al. (2006). "In Vivo Restoration of Physiological Levels of Truncated TrkB.T1 Receptor Rescues Neuronal Cell Death in a Trisomic Mouse Model." Neuron 51(1): 21-8.PMID: 16815329
Dowdy-Sanders, N. C. and G. R. Wenger (2006). "Working memory in the Ts65Dn mouse, a model for Down syndrome." Behav Brain Res 168(2): 349-52. PMID: 16386318
Epstein, C. J. (2006). "Down's syndrome: critical genes in a critical region." Nature 441(7093): 582-3. PMID: 16738647
Harashima, C., D. M. Jacobowitz, et al. (2006). "Elevated Expression of the G-Protein-Activated Inwardly Rectifying Potassium Channel 2 (GIRK2) in Cerebellar Unipolar Brush Cells of a Down Syndrome Mouse Model." Cell Mol Neurobiol. PMID: 16783527
Harashima, C., D. M. Jacobowitz, et al. (2006). "Abnormal expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in hippocampus, frontal cortex, and substantia nigra of Ts65Dn mouse: a model of Down syndrome." J Comp Neurol 494(5): 815-33. PMID: 16374808
Jablonska B, Ford D, Trisler D, Pessac B. (2006). ÒThe growth capacity of bone marrow CD34 positive cells in culture is drastically reduced in a murine model of Down syndrome.Ó C R Biol. 329(9):726-32. PMID: 16945839
Lorenzi, H. A. and R. H. Reeves (2006). "Hippocampal hypocellularity in the Ts65Dn mouse originates early in development." Brain Res. PMID: 16828061
Ma'ayan A, Gardiner K, Iyengar R. (2006). ÒThe cognitive phenotype of Down syndrome: insights from intracellular network analysis.Ó Neuro Rx. 3(3):396-406. Review.PMID: 16815222
Martinez-Cue, C., N. Rueda, et al. (2006). "Anxiety and panic responses to a predator in male and female Ts65Dn mice, a model for Down syndrome." Genes Brain Behav 5(5): 413-22. PMID: 16879635
Opazo P, Saud K, de Saint Pierre M, C‡rdenas AM, Allen DD, Segura-Aguilar J, Caviedes R, Caviedes P. (2006). ÒKnockdown of amyloid precursor protein normalizes cholinergic function in a cell line derived from the cerebral cortex of a trisomy 16 mouse: An animal model of down syndrome.Ó J Neurosci Res 84(6):1303-10. PMID: 16941497
Potier, M. C., I. Rivals, et al. (2006). "Transcriptional disruptions in Down syndrome: a case study in the Ts1Cje mouse cerebellum during post-natal development." J Neurochem 97 Suppl 1: 104-9. PMID: 16635258
Reeves RH. (2006). ÒDown syndrome mouse models are looking up.ÓTrends Mol Med. 12(6):237-40. PMID: 16677859
Roper, R. J. and R. H. Reeves (2006). "Understanding the basis for Down syndrome phenotypes." PLoS Genet 2(3): e50. PMID: 16596169
Roper, R. J., L. L. Baxter, et al. (2006). "Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice." Proc Natl Acad Sci U S A 103(5): 1452-6. PMID: 16432181
Roper, R. J., H. K. St John, et al. (2006). "Perinatal loss of Ts65Dn Down syndrome mice." Genetics 172(1): 437-43. PMID: 16172497
Roubertoux PL, Bichler Z, Pinoteau W, Jamon M, SŽrŽgaza Z, Smith DJ, Rubin E, Migliore-Samour D. (2006). ÒPre-weaning sensorial and motor development in mice transpolygenic for the critical region of trisomy 21.Ó Behav Genet. 36(3):377-86. PMID: 16514474
Salehi, A., J. D. Delcroix, et al. (2006). "Increased App Expression in a Mouse Model of Down's Syndrome Disrupts NGF Transport and Causes Cholinergic Neuron Degeneration." Neuron 51(1): 29-42.PMID: 16815330
Sahir N, Brenneman DE, Hill JM. (2006). ÒNeonatal mice of the Down syndrome model, Ts65Dn, exhibit upregulated VIP measures and reduced responsiveness of cortical astrocytes to VIP stimulation.Ó J Mol Neurosci. 30(3):329-40. PMID: 17401158
Seregaza, Z., P. L. Roubertoux, et al. (2006). "Mouse models of cognitive disorders in trisomy 21: a review." Behav Genet 36(3): 387-404. PMID: 16523244
Shukkur EA, Shimohata A, Akagi T, Yu W, Yamaguchi M, Murayama M, Chui D, Takeuchi T, Amano K, Subramhanya KH, Hashikawa T, Sago H, Epstein CJ, Takashima A, Yamakawa K. (2006). ÒMitochondrial dysfunction and tau hyperphosphorylation in Ts1Cje, a mouse model for Down syndrome.Ó Hum Mol Genet. 15(18):2752-62. PMID: 16891409
Siarey RJ, Kline-Burgess A, Cho M, Balbo A, Best TK, Harashima C, Klann E, Galdzicki Z. (2006). ÒAltered signaling pathways underlying abnormal hippocampal synaptic plasticity in the Ts65Dn mouse model of Down syndrome.Ó J Neurochem. 2006 98(4):1266-77. Erratum in: J Neurochem. 99(4):1320. PMID: 16895585
Stasko MR, Scott-McKean JJ, Costa AC. (2006). ÒHypothermic responses to 8-OH-DPAT in the Ts65Dn mouse model of Down syndrome.Ó Neuroreport. 17(8):837-41.PMID: 16708025
Costa, A.C., Stasko M.R., Stoffel M. and Scott-McKean J.J. (2005) G-protein-gated potassium (GIRK) channels containing the GIRK2 subunit are control hubs for pharmacologically induced hypothermic responses. J Neurosci 25(34):7801-4. PMID: 16120781
Costa, A. C. and M. J. Grybko (2005). "Deficits in hippocampal CA1 LTP induced by TBS but not HFS in the Ts65Dn mouse: A model of Down syndrome." Neurosci Lett 382(3): 317-22. PMID: 15925111
Dauphinot, L., Lyle, R. et al. (2005) The cerebellar transcriptome during postnatal development of the Ts1Cje mouse, a segmental trisomy model for Down syndrome Human Molecular Genetics 14(3):373-384 PMID: 15590701
Gardiner, K., Davisson M. T. et al. (2005). "Report on the 'Expert Workshop on the Biology of Chromosome 21: towards gene-phenotype correlations in Down syndrome', held June 11-14, 2004, Washington D.C." Cytogenet Genome Res 108(4): 269-77. PMID:15627744
Lange, A. W., B. A. Rothermel, et al. (2005). "Restoration of DSCR1 to disomy in the trisomy 16 mouse model of Down syndrome does not correct cardiac or craniofacial development anomalies." Dev Dyn 233(3): 954-63. PMID: 15906378
Martinez-Cue, C., N. Rueda, et al. (2005). "Behavioral, cognitive and biochemical responses to different environmental conditions in male Ts65Dn mice, a model of Down syndrome." Behav Brain Res. PMID: 15941601
O'Doherty, A., S. Ruf, et al. (2005). "An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes." Science 309(5743): 2033-7. PMID: 16179473
Patterson, D. and Costa A.C. (2005). "Down syndrome and genetics - a case of linked histories." Nat Rev Genet 6(2): 137-47. pmid: 15640809
Ramakrishna, N., C. Meeker, et al. (2005). "Polymerase chain reaction method to identify Down syndrome model segmentally trisomic mice." Anal Biochem 340(2): 213-9.PMID: 15840493
Rueda, N., R. Mostany, et al. (2005). "Cell proliferation is reduced in the dentate gyrus of aged but not young Ts65Dn mice, a model of Down syndrome." Neurosci Lett 380(1-2): 197-201. PMID:15854777
Siarey, R. J., A. J. Villar, et al. (2005). "Abnormal synaptic plasticity in the Ts1Cje segmental trisomy 16 mouse model of Down syndrome." Neuropharmacology 49(1): 122-8. PMID: 15992587
Seo, H. and O. Isacson (2005). "Abnormal APP, cholinergic and cognitive function in Ts65Dn Down's model mice." Exp Neurol 193(2): 469-80.PMID: 15869949
Vacik, T., M. Ort, et al. (2005). "Segmental trisomy of chromosome 17: a mouse model of human aneuploidy syndromes." Proc Natl Acad Sci U S A 102(12): 4500-5.PMID: 15755806
Villar, A. J., Belichenko, P.V. et al. (2005) 'Identification and characterization of a new Down syndrome model, Ts[Rb(12.17<16>)2Cje, resulting from a spontaneous Robertsonian fusion between T(17<16>)65Dn and mouse Chromosome 12". Mamm Genome 16(2):79-90. PMID: 15859352
Villar, A. J., J. Kim, et al. (2005). "Effects of genetic background on cardiovascular anomalies in the Ts16 mouse." Dev Dyn 232(1): 131-9. PMID: 15580624
Belichenko, P. V., Masliah E. et al. (2004). "Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome." J Comp Neurol 480(3): 281-98. PMID: 15515178
Cheng, A., T. F. Haydar, et al. (2004). "Concurrent generation of subplate and cortical plate neurons in developing trisomy 16 mouse cortex." Dev Neurosci 26(2-4): 255-65. PMID: 15711065
Driscoll, L. L., J. C. Carroll, et al. (2004). "Impaired sustained attention and error-induced stereotypy in the aged Ts65Dn mouse: a mouse model of Down syndrome and Alzheimer's disease." Behav Neurosci 118(6): 1196-205. PMID: 15598129
Gardiner, K. (2004). "Gene-dosage effects in Down syndrome and trisomic mouse models." Genome Biol 5(10): 244. PMID: 15461808
Gardiner, K., Davisson M. T, et al. (2004). "Building protein interaction maps for Down's syndrome." Brief Funct Genomic Proteomic 3(2): 142-56. PMID: 15355596
Gotti, S., Chiavegatto, S. et al. (2004). "Alteration of NO-producing system in the basal forebrain and hypothalamus of Ts65Dn mice: an immunohistochemical and histochemical study of a murine model for Down syndrome." Neurobiol Dis 16(3): 563-71. PMID: 15262268
Hampton, T. G., Stasko, M. R. et al. (2004). "Gait dynamics in trisomic mice: quantitative neurological traits of Down syndrome." Physiol Behav 82(2-3): 381-9. PMID: 15276802
Hunter, C. L., Bimonte-Nelson, H. A. et al. (2004). "Behavioral and neurobiological markers of Alzheimer's disease in Ts65Dn mice: Effects of estrogen." Neurobiol Aging 25(7): 873-84. PMID: 15212841
Kahlem, P., Sultan M. et al. (2004). "Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of down syndrome." Genome Res 14(7): 1258-67. PMID: 15231742
Kleschevnikov, A. M., Belichenko P. V. et al. (2004). "Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome." J Neurosci 24(37): 8153-60. PMID: 15371516
Kurt, M. A., M. I. Kafa, et al. (2004). "Deficits of neuronal density in CA1 and synaptic density in the dentate gyrus, CA3 and CA1, in a mouse model of Down syndrome." Brain Res 1022(1-2): 101-9. PMID: 15353219
Lyle, R., Gehrig C. et al. (2004). "Gene expression from the aneuploid chromosome in a trisomy mouse model of down syndrome." Genome Res 14(7): 1268-74. PMID:15231743
O'Leary, D. A., M. A. Pritchard, et al. (2004). "Tissue-specific overexpression of the HSA21 gene GABPalpha: implications for DS." Biochim Biophys Acta 1739(1): 81-7. PMID: 15607120
Olson, L. E., Richtsmeier J. T. et al. (2004). "A chromosome 21 critical region does not cause specific Down syndrome phenotypes." Science 306(5696): 687-90. PMID:15499018
Olson, L. E., Roper, R. J. et al. (2004). "Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes." Dev Dyn 230(3): 581-9. PMID: 15188443
Stasko, M. R. and A. C. Costa (2004). "Experimental parameters affecting the Morris water maze performance of a mouse model of Down syndrome." Behav Brain Res 154(1): 1-17. PMID: PMID: 15302106
Wenger, G. R., Schmidt C., Davisson,M.T. (2004). "Operant conditioning in the Ts65Dn mouse: learning." Behav Genet 34(1): 105-19. Wenger, G. R., Schmidt C., Davisson,M.T. (2004). "Operant conditioning in the Ts65Dn mouse: learning." Behav Genet 34(1): 105-19. PMID: 14739701
2003
Bambrick LL, Yarowsky PJ, Krueger BK. Altered astrocyte calcium homeostasis and proliferation in theTs65Dn mouse, a model of Down syndrome. J Neurosci Res. 2003 Jul 1;73(1):89-94. PMID: 12815712
Bimonte-Nelson HA, Hunter CL, Nelson ME, Granholm AC. Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome. Behav Brain Res. 2003 Feb 17;139(1-2):47-57. PMID: 12642175
Cataldo AM, Petanceska S, Peterhoff CM, Terio NB, Epstein CJ, Villar A, Carlson EJ, Staufenbiel M, Nixon RA. App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome. J Neurosci. 2003 Jul 30;23(17):6788-92. PMID: 12890772
Dierssen M, Benavides-Piccione R, Martinez-Cue C, Estivill X, Florez J, ElstonGN, DeFelipe J. Alterations of neocortical pyramidal cell phenotype in the Ts65Dn mouse model of Down syndrome: effects of environmental enrichment. Cereb Cortex. 2003 Jul;13(7):758-64. PMID: 12816891
Galdzicki Z, Siarey RJ. Understanding mental retardation in Down's syndrome using trisomy 16 mouse models. Genes Brain Behav. 2003 Jun;2(3):167-78. PMID: 12931790
Gardiner, K. (2003). "Predicting pathway perturbations in Down syndrome." J Neural Transm Suppl (67): 21-37. PMID: 15068236
Gardiner, K., Fortna, A. et al. (2003). "Mouse models of Down syndrome: how useful can they be? Comparison of the gene content of human chromosome 21 with orthologous mouse genomic regions." Gene 318: 137-47. PMID: 14585506
Granholm, A. C., Sanders, L. et al. (2003). "Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome." Hippocampus 13(8): 905-14. PMID: 14750653
Hill, J. M., Ades, A. M. et al. (2003). "Vasoactive intestinal peptide in the brain of a mouse model for Down syndrome." Exp Neurol 183(1): 56-65. PMID: 12957488
Hunter CL, Bimonte HA, Granholm AC. Behavioral comparison of 4 and 6 month-old Ts65Dn mice: age-related impairments in working and reference memory. Behav Brain Res. 2003 Jan 22;138(2):121-31. PMID: 12527443
Hunter CL, Isacson O, Nelson M, Bimonte-Nelson H, Seo H, Lin L, Ford K, Kindy MS, Granholm AC. Regional alterations in amyloid precursor protein and nerve growth factor across age in a mouse model of Down's syndrome. Neurosci Res. 2003 Apr;45(4):437-45. PMID: 12657457
Salehi, A., J. D. Delcroix, et al. (2003). "Traffic at the intersection of neurotrophic factor signaling and neurodegeneration." Trends Neurosci 26(2): 73-80. PMID: 12536130
Saran NG, Pletcher MT, Natale JE, Cheng Y, Reeves RH. Global disruption of the cerebellar transcriptome in a Down syndrome mouse model. Hum Mol Genet. 2003 Aug 15;12(16):2013-9. PMID: 12913072
Vacik, T. and J. Forejt (2003). "Quantification of expression and methylation of the Igf2r imprinted gene in segmental trisomic mouse model." Genomics 82(3): 261-8.PMID: 12906851
2002
Dorsey SG, Bambrick LL, Balice-Gordon RJ, Krueger BK. Failure of brain-derived neurotrophic factor-dependent neuron survival in mouse trisomy 16. J Neurosci. 2002 Apr 1;22(7):2571-8. Erratum in: J Neurosci 2002 May 1;22(9):following Table of contents. PMID: 11923422
Granholm AC, Ford KA, Hyde LA, Bimonte HA, Hunter CL, Nelson M, Albeck D, Sanders LA, Mufson EJ, Crnic LS. Estrogen restores cognition and cholinergic phenotype in an animal model of Down syndrome. Physiol Behav. 2002 Nov;77(2-3):371-85. PMID: 12419414
Hyde LA, Crnic LS. Reactivity to object and spatial novelty is normal in older Ts65Dn mice that model Down syndrome and Alzheimer's disease. Brain Res. 2002 Jul 26;945(1):26-30. PMID: 12113948
Martinez-Cue C, Baamonde C, Lumbreras M, Paz J, Davisson MT, Schmidt C, Dierssen M, Florez J. Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for Down syndrome. Behav Brain Res. 2002 Aug 21;134(1-2):185-200. PMID: 12191805
Moran TH, Capone GT, Knipp S, Davisson MT, Reeves RH, Gearhart JD. The effects of piracetam on cognitive performance in a mouse model of Down's syndrome. Physiol Behav. 2002 Nov;77(2-3):403-9. PMID: 12419416
Richtsmeier JT, Zumwalt A, Carlson EJ, Epstein CJ, Reeves RH. Craniofacial phenotypes in segmentally trisomic mouse models for Down syndrome. Am J Med Genet. 2002 Feb 1;107(4):317-24. PMID: 11840489
Akeson, E. C.Lambert, J. P.Narayanswami, S.Gardiner, K.Bechtel, L. J.Davisson, M. T. 2001 Ts65Dn -- localization of the translocation breakpoint and trisomic gene content in a mouse model for Down syndrome Cytogenet Cell Genet 93:270 -276. PMID: 11528125
Cairns NJ. Molecular neuropathology of transgenic mouse models of Down syndrome. J Neural Transm Suppl. 2001;(61):289-301. Review. PMID: 11771752
Casas C, Martinez S, Pritchard MA, Fuentes JJ, Nadal M, Guimera J, Arbones M, Florez J, Soriano E, Estivill X, Alcantara S. Dscr1, a novel endogenous inhibitor of calcineurin signaling, is expressed in the primitive ventricle of the heart and during neurogenesis. Mech Dev. 2001 Mar;101(1-2):289-92. PMID: 11231093
Cooper JD, Salehi A, Delcroix JD, Howe CL, Belichenko PV, Chua-Couzens J, Kilbridge JF, Carlson EJ, Epstein CJ, Mobley WC. 2001. Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion. Proc Natl Acad Sci U S A 98:10439-44. PMID:11504920
Davisson, M. T.,Bechtel, L. J. Akeson, E. C. Fortna, A. Slavov, D. K. Gardiner. 2001 Evolutionary breakpoints on human chromosome 21. Genomics 78: 1-2 : 99-106. PMID:11707078
Galdzicki Z, Siarey R, Pearce R, Stoll J, Rapoport SI. On the cause of mental retardation in Down syndrome: extrapolation from full and segmental trisomy 16 mouse models. Brain Res Brain Res Rev. 2001 Apr;35(2):115-45. Review. PMID: 11336779
Hyde LA, Crnic LS. 2001. Age-related deficits in context discrimination learning in Ts65Dn mice that model Down syndrome and Alzheimer's disease. Behav Neurosci 115:1239-46.PMID: 11770055
Hyde LA, Crnic LS, Pollock A, Bickford PC. Motor learning in Ts65Dn mice, a model for Down syndrome. Dev Psychobiol. 2001 Jan;38(1):33-45. Erratum in: Dev Psychobiol 2001 Apr;38(3):219. PMID: 11150059
Hyde LA, Frisone DF, Crnic LS. Ts65Dn mice, a model for Down syndrome, have deficits in context discrimination learning suggesting impaired hippocampal function. Behav Brain Res. 2001 Jan 8;118(1):53-60. PMID: 11163633
Klein RC, Siarey RJ, Caruso A, Rapoport SI, Castellino FJ, Galdzicki Z. Increased expression of NR2A subunit does not alter NMDA-evoked responses in cultured fetal trisomy 16 mouse hippocampal neurons. J Neurochem. 2001 Mar;76(6):1663-9. PMID: 11259484
Paz-Miguel JE, Pardo-Manuel de Villena F, Sanchez-Velasco P, Leyva-Cobian F. H2-haplotype-dependent unequal transmission of the 17(16) translocation chromosome from Ts65Dn females. Mamm Genome. 2001 Jan;12(1):83-5. No abstract available. PMID: 11178750
Ruiz de Azua I, Lumbreras MA, Zalduegui A, Baamonde C, Dierssen M, Florez J, Salles J. 2001. Reduced phospholipase C-beta activity and isoform expression in the cerebellum of TS65Dn mouse: a model of Down syndrome. J Neurosci Res 66:540-50. PMID:11746373
Shapiro BL. Developmental instability of the cerebellum and its relevance to Down syndrome. J Neural Transm Suppl. 2001;(61):11-34. Review. PMID: 11771737
Turner, C.A., Presti, M.F., Newman, H.A., Bugnehagen, P., Crnic, L., and Lewis, M.H. Spontaneous stereotypy in an animal model of Down syndrome. Behavior Genetics, 2001, 31, 393-400. PMID: 11720125
2000
Allen, D. D., Martin, J. et al. (2000). "Impaired cholinergic function in cell lines derived from the cerebral cortex of normal and trisomy 16 mice [In Process Citation]." Eur J Neurosci 12(9): 3259-64. PMID: 10998109
Baxter LL, Moran TH, Richtsmeier JT, Troncoso J, Reeves RH. Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouse. Hum Mol Genet. 2000 Jan 22;9(2):195-202. PMID: 10607830
Berg BM, Croom J, Fernandez JM, Spears JW, Eisen EJ, Taylor IL, Daniel LR, Coles BA, Boeheim F, Mannon PJ. Peptide YY administration decreases brain aluminum in the Ts65Dn Down syndrome mouse model. Growth Dev Aging. 2000 Spring-Summer;64(1-2):3-19. PMID: 10969882
Chrast R, Scott HS, Papasavvas MP, Rossier C, Antonarakis ES, Barras C, Davisson MT, Schmidt C, Estivill X, Dierssen M, Pritchard M, Antonarakis SE. The mouse brain transcriptome by SAGE: differences in gene expression between P30 brains of the partial trisomy 16 mouse model of Down syndrome (Ts65Dn) and normals. Genome Res. 2000 Dec;10(12):2006-21. PMID: 11116095
Chrast, R., Scott, H. S. et al. (2000). "Mice trisomic for a bacterial artificial chromosome with the single-minded 2 gene (Sim2) show phenotypes similar to some of those present in the partial trisomy 16 mouse models of Down syndrome." Hum Mol Genet 9(12): 1853-64. PMID: 10915774
Granholm AC, Sanders LA, Crnic LS. Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome. Exp Neurol. 2000 Feb;161(2):647-63. PMID: 10686084
Haydar TF, Nowakowski RS, Yarowsky PJ, Krueger BK. Role of founder cell deficit and delayed neuronogenesis in microencephaly of the trisomy 16 mouse. J Neurosci. 2000 Jun 1;20(11):4156-64. PMID: 10818151
Huang W, Galdzicki Z, van Gelderen P, Balbo A, Chikhale EG, Schapiro MB, Rapoport SI. Brain myo-inositol level is elevated in Ts65Dn mouse and reduced after lithium treatment. Neuroreport. 2000 Feb 28;11(3):445-8. PMID: 10718292
Kurt MA, Davies DC, Kidd M, Dierssen M, Florez J. Synaptic deficit in the temporal cortex of partial trisomy 16 (Ts65Dn) mice. Brain Res. 2000 Mar 6;858(1):191-7. PMID: 10700614
Peng S, Rapoport SI, Pearce RJ, Galdzicki Z. Abnormal chloride and potassium conductances in cultured embryonic tongue muscle from trisomy 16 mouse. Brain Res Dev Brain Res. 2000 Aug 30;122(2):193-7. PMID: 10960688
Richtsmeier JT, Baxter LL, Reeves RH. Parallels of craniofacial maldevelopment in Down syndrome and Ts65Dn mice. Dev Dyn. 2000 Feb;217(2):137-45. PMID: 10706138
Sago H, Carlson EJ, Smith DJ, Rubin EM, Crnic LS, Huang TT, Epstein CJ. Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome. Pediatr Res. 2000 Nov;48(5):606-13. PMID: 11044479
Schuchmann S, Heinemann U. Diminished glutathione levels cause spontaneous and mitochondria-mediated cell death in neurons from trisomy 16 mice: a model of Down's syndrome. J Neurochem. 2000 Mar;74(3):1205-14. PMID: 10693953
Schuchmann S, Heinemann U. Increased mitochondrial superoxide generation in neurons from trisomy 16 mice: a model of Down's syndrome. Free Radic Biol Med. 2000 Jan 15;28(2):235-50. PMID: 11281291
Shetty HU, Siarey RJ, Galdzicki Z, Stoll J, Rapoport SI. Ts65Dn mouse, a Down syndrome model, exhibits elevated myo-inositol in selected brain regions and peripheral tissues. Neurochem Res. 2000 Apr;25(4):431-5. PMID:10823574
Truett, G.E., Heeger, P., Mynatt, R.L., Truett, A.A., Walker, J.A. and Warman, M.L.
Preparation of PCR-quality mouse genomic DNA with hot sodium hydroxide and tris (HotShot). Biotewchniques.2000 Jul: 29(1): 52, 54 PMID: 10907076
Waller BR 3rd, McQuinn T, Phelps AL, Markwald RR, Lo CW, Thompson RP, Wessels A. Conotruncal anomalies in the trisomy 16 mouse: an immunohistochemical analysis with emphasis on the involvement of the neural crest. Anat Rec. 2000 Nov 1;260(3):279-93. PMID: 11066038
Yao FS, Caserta MT, Wyrwicz AM. In vitro 1H and 31P NMR spectroscopic evidence of multiple aberrant biochemical pathways in murine trisomy 16 brain development. Int J Dev Neurosci. 2000 Dec;18(8):833-41. PMID: 11154853
1999
Bambrick LL, Krueger BK. Neuronal apoptosis in mouse trisomy 16: mediation by caspases. J Neurochem. 1999 Apr;72(4):1769-72. PMID: 10098888
Costa ACS, Walsh K, Davisson MT. Motor dysfunction in a mouse model for Down syndrome. In: Physiology & Behavior, Volume 68, Elsevier Science, pp. 211-220, (in press). PMID: 10627083
Davisson MT, Costa ACS. Mouse models of Down syndrome. In: Mouse Models in the study of Genetic Neurological Disorders, Volume 9 of Advances in Neurochemistry, Popko B(ed), Plenum Press, pp. 297-327.
Davisson MT, Costa ACS. Ts65Dn - A Mouse Model of Down Syndrome. In: Les Modeles animaux de maladies humaine genetiquement determinees, Annales de l'Institute Pasteur - Actualaites. Guenet J-L, Montagutelli X, Jaubert J (eds).
Gjertson C, Sturm KS, Berger CN. Hematopoietic deficiencies and core binding factor expression in murine Ts16, an animal model for Down syndrome. Clin Immunol. 1999 Apr;91(1):50-60. PMID: 10219254
Guimera J, Casas C, Estivill X, Pritchard M. Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome. Genomics. 1999 May 1;57(3):407-18. PMID: 10329007
Martinez-Cue C, Baamonde C, Lumbreras MA, Vallina IF, Dierssen M, Florez J. A murine model for Down syndrome shows reduced responsiveness to pain. Neuroreport. 1999 Apr 6;10(5):1119-22. PMID: 10321494
Paz-Miguel JE, Flores R, Sanchez-Velasco P, Ocejo-Vinyals G, Escribano de Diego J, Lopez de Rego J, Leyva-Cobian F. Reactive oxygen intermediates during programmed cell death induced in the thymus of the Ts(1716)65Dn mouse, a murine model for human Down's syndrome. J Immunol. 1999 Nov 15;163(10):5399-410. PMID: 10553065
Siarey RJ, Carlson EJ, Epstein CJ, Balbo A, Rapoport SI, Galdzicki Z. Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome. Neuropharmacology. 1999 Dec;38(12):1917-20. PMID: 10608287
Strovel J, Stamberg J, Yarowsky PJ. Interphase FISH for rapid identification of a down syndrome animal model. Cytogenet Cell Genet. 1999;86(3-4):285-7. PMID: 10575227
1998
Cefalu JA, Croom WJ Jr, Eisen EJ, Jones EE, Daniel LR, Taylor IL. Jejunal function and plasma amino acid concentrations in the segmental trisomic Ts65Dn mouse. Growth Dev Aging. 1998 Spring-Summer;62(1-2):47-59. PMID: 9666356
Corsi P, Forloni G, Troia M, Lettini T, Coyle JT. Somatostatin expression in TS16 mouse brain cultures. J Mol Neurosci. 1998 Apr;10(2):99-111. PMID: 9699151
Demas GE, Nelson RJ, Krueger BK, Yarowsky PJ. Impaired spatial working and reference memory in segmental trisomy (Ts65Dn) mice. Behav Brain Res. 1998 Feb;90(2):199-201. PMID: 9521551
Escorihuela RM, Vallina IF, Martinez-Cue C, Baamonde C, Dierssen M, Tobena A, Florez J, Fernandez-Teruel A. Impaired short- and long-term memory in Ts65Dn mice, a model for Down syndrome. Neurosci Lett. 1998 May 15;247(2-3):171-4. PMID: 9655620
Galdzicki Z, Coan EJ, Rapoport SI, Stoll J. Increased expression of voltage-activated calcium channels in cultured hippocampal neurons from mouse trisomy 16, a model for Down syndrome. Brain Res Mol Brain Res. 1998 May;56(1-2):200-6. PMID: 9602127
Insausti AM, Megias M, Crespo D, Cruz-Orive LM, Dierssen M, Vallina IF, Insausti R, Florez J, Vallina TF, Vallina TF. Hippocampal volume and neuronal number in Ts65Dn mice: a murine model of Down syndrome. Neurosci Lett. 1998 Sep 11;253(3):175-8. Erratum in: Neurosci Lett 1998 Dec 24;258(3):190. PMID: 9792239
Kola I, Hertzog PJ. Down syndrome and mouse models. Curr Opin Genet Dev. 1998 Jun;8(3):316-21. Review. PMID: 9690992
Sago H, Carlson EJ, Smith DJ, Kilbridge J, Rubin EM, Mobley WC, Epstein CJ, Huang TT. Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities. Proc Natl Acad Sci U S A. 1998 May 26;95(11):6256-61. PMID: 9600952
Schuchmann S, Muller W, Heinemann U. Altered Ca2+ signaling and mitochondrial deficiencies in hippocampal neurons of trisomy 16 mice: a model of Down's syndrome. J Neurosci. 1998 Sep 15;18(18):7216-31. PMID: 9736644
1997
Bambrick LL, Golovina VA, Blaustein MP, Yarowsky PJ, Krueger BK. Abnormal calcium homeostasis in astrocytes from the trisomy 16 mouse. Glia. 1997 Apr;19(4):352-8. PMID: 9097079
Dierssen M, Vallina IF, Baamonde C, Garcia-Calatayud S, Lumbreras MA, Florez J. Alterations of central noradrenergic transmission in Ts65Dn mouse, a model for Down syndrome. Brain Res. 1997 Feb 28;749(2):238-44. PMID: 9138724
Megias M, Verduga R, Dierssen M, Florez J, Insausti R, Crespo D. Cholinergic, erotonergic and catecholaminergic neurons are not affected in Ts65Dn mice. Neuroreport. 1997 Nov 10;8(16):3475-8. PMID: 9427310
Muller W, Heinemann U, Schuchmann S. Impaired Ca-signaling in astrocytes from the Ts16 mouse model of Down syndrome. Neurosci Lett. 1997 Feb 21;223(2):81-4. PMID: 9089678
Nelson PG, Fitzgerald S, Rapoport SI, Neale EA, Galdzicki Z, Dunlap V, Bowers L, v Agoston D. Cerebral cortical astroglia from the trisomy 16 mouse, a model for down syndrome, produce neuronal cholinergic deficits in cell culture. Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12644-8. PMID: 9356503
Siarey RJ, Coan EJ, Rapoport SI, Galdzicki Z. Responses to NMDA in cultured hippocampal neurons from trisomy 16 embryonic mice. Neurosci Lett. 1997 Sep 5;232(3):131-4. PMID: 9310297
Siarey RJ, Stoll J, Rapoport SI, Galdzicki Z. Altered long-term potentiation in the young and old Ts65Dn mouse, a model for Down Syndrome. Neuropharmacology. 1997 Nov-Dec;36(11-12):1549-54. PMID: 9517425
Webb S, Brown NA, Anderson RH. Cardiac morphology at late fetal stages in the mouse with trisomy 16: consequences for different formation of the atrioventricular junction when compared to humans with trisomy 21. Cardiovasc Res. 1997 Jun;34(3):515-24. PMID: 9231034
1996
Coussons-Read ME, Crnic LS. Behavioral assessment of the Ts65Dn mouse, a model for Down syndrome: altered behavior in the elevated plus maze and open field. Behav Genet. 1996 Jan;26(1):7-13. PMID: 8852727
Demas GE, Nelson RJ, Krueger BK, Yarowsky PJ. Spatial memory deficits in segmental trisomic Ts65Dn mice. Behav Brain Res. 1996 Dec;82(1):85-92. PMID: 9021073
Frederiksen K, Thorpe A, Richards SJ, Waters J, Dunnett SB, Sandberg BE. Immortalized neural cells from trisomy 16 mice as models for Alzheimer's disease. Ann N Y Acad Sci. 1996 Jan 17;777:415-20. PMID: 8624123
Haydar TF, Blue ME, Molliver ME, Krueger BK, Yarowsky PJ. Consequences of trisomy 16 for mouse brain development: corticogenesis in a model of Down syndrome. J Neurosci. 1996 Oct 1;16(19):6175-82. PMID: 8815899
Holtzman DM, Santucci D, Kilbridge J, Chua-Couzens J, Fontana DJ, Daniels SE, Johnson RM, Chen K, Sun Y, Carlson E, Alleva E, Epstein CJ, Mobley WC. Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13333-8. PMID: 97075165
Klein SL, Kriegsfeld LJ, Hairston JE, Rau V, Nelson RJ, Yarowsky PJ. Characterization of sensorimotor performance, reproductive and aggressive behaviors in segmental trisomic 16 (Ts65Dn) mice. Physiol Behav. 1996 Oct;60(4):1159-64. PMID: 8884947
Lane NJ, Balbo A, Rapoport SI. A fine structural study of the hippocampus and dorsal root ganglion in mouse trisomy 16, a model of Down's syndrome. Cell Biol Int. 1996 Oct;20(10):673-80. PMID: 8969460
Stoll J, Galdzicki Z. Reduced expression of voltage-gated sodium channels in neurons cultured from trisomy 16 mouse hippocampus. Int J Dev Neurosci. 1996 Oct;14(6):749-60. PMID: 8960982
Webb S, Anderson RH, Brown NA. Endocardial cushion development and heart loop architecture in the trisomy 16 mouse. Dev Dyn. 1996 Jul;206(3):301-9. PMID: 8896985
1995
Bambrick LL, Yarowsky PJ, Krueger BK. Glutamate as a hippocampal neuron survival factor: an inherited defect in the trisomy 16 mouse. Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9692-6. PMID: 7568199
Escorihuela RM, Fernandez-Teruel A, Vallina IF, Baamonde C, Lumbreras MA, Dierssen M, Tobena A, Florez J. A behavioral assessment of Ts65Dn mice: a putative Down syndrome model.Neurosci Lett. 1995 Oct 20;199(2):143-6. PMID: 8584244
Reeves RH, Irving NG, Moran T, Wohn A, Sissodia SS, Schmidt C, Davisson MT. 1995. A mouse model for Down Syndrome exhibits learning and behavior deficits. Nature Genet 11(Oct): 177-84. PMID:7550346
1994
Di Stefano TV, Provenza DV. Osteogenesis of the mandibular arch in Ts16 mice. Arch Oral Biol. 1994 Feb;39(2):121-33. PMID: 8185497
Fiedler JL, Epstein CJ, Rapoport SI, Caviedes R, Caviedes P. Regional alteration of cholinergic function in central neurons of trisomy 16 mouse fetuses, an animal model of human trisomy 21 (Down syndrome). Brain Res. 1994 Sep 26;658(1-2):27-32. PMID: 7834352
Lacey-Casem ML, Oster-Granite ML. The neuropathology of the trisomy 16 mouse. Crit Rev Neurobiol. 1994;8(4):293-322. Review. PMID: 7850875
Lane NJ, Balbo A, Stoll J, Rapoport SI. Long-term intracerebral transplants of fetal hippocampus from mouse trisomy 16, a model for Down's syndrome (trisomy 21), do not exhibit Alzheimer's disease neuropathology by ultrastructural criteria. Tissue Cell. 1994 Aug;26(4):477-88. Erratum in: 1994 Cell 1994 Oct;26(5):796. PMID: 8091421
1993
Davisson MT, Schmidt C, Reeves RM, Irving NG, Akeson EC, Harris BS, Bronson RT. 1993. Segmental trisomy as a model for Down Syndrome and other Aneuploid Conditions. In: The Phenotypic Mapping of Down Syndrome and Other Aneuploid Conditions. Wiley-Liss, New York, pp. 117-33. PMID: 8115398
1992
Berger CN, Epstein CJ. Deficient transformation of murine trisomy 16 fetal liver cells by the Abelson and J2 viruses. Immunol Lett. 1992 Jun;33(1):47-51. PMID: 1427990
Ewart JL, Auerbach R. Defects in thymocyte differentiation and thymocyte-stromal interactions in the trisomy 16 mouse. Dev Immunol. 1992;2(3):215-26. PMID: 1378332
Kornguth S, Bersu E, Anderson M, Markley J. Correlation of increased levels of class I MHC H-2Kk in the placenta of murine trisomy 16 conceptuses with structural abnormalities revealed by magnetic resonance microscopy. Teratology. 1992 Apr;45(4):383-91. PMID: 1533959
1991
Capone GT, Bendotti C, Oster-Granite ML, Coyle JT. Developmental expression of the gene encoding growth-associated protein 43 (Gap43) in the brains of normal and aneuploid mice. J Neurosci Res. 1991 Aug;29(4):449-60. PMID: 1838777
Colton CA, Yao J, Taffs RE, Keri JE, Oster-Granite ML. Abnormal production of interleukin-1 by microglia from trisomy 16 mice. Neurosci Lett. 1991 Nov 11;132(2):270-4. PMID: 1723792
Corsi P, Coyle JT. Nerve growth factor corrects developmental impairments of basal forebrain cholinergic neurons in the trisomy 16 mouse. Proc Natl Acad Sci U S A. 1991 Mar 1;88(5):1793-7. PMID: 2000385
Coyle, J. T., Oster-Granite, M.L. et al. (1991). "Down syndrome and the trisomy 16 mouse: impact of gene imbalance on brain development and aging." Res Publ Assoc Res Nerv Ment Dis 69: 85-99. PMID: 1825889
1990
Caviedes P, Ault B, Rapoport SI. Electrical membrane properties of cultured dorsal root ganglion neurons from trisomy 19 mouse fetuses: a comparison with the trisomy 16 mouse fetus, a model for Down syndrome. Brain Res. 1990 Mar 12;511(1):169-72. PMID: 2139588
Colton CA, Yao JB, Gilbert D, Oster-Granite ML. Enhanced production of superoxide anion by microglia from trisomy 16 mice. Brain Res. 1990 Jun 11;519(1-2):236-42. PMID: 2168783
Davisson MT, Schmidt C, Akeson EC. 1990. Segmental trisomy of murine chromosome 16: A new model system for studying Down syndrome. In: Molecular Genetics of Chromosome 21 and Down Syndrome, Epstein C, Patterson D (eds), Wiley-Liss, Inc, New York, Progress in Clinical and Biological Research 360:263-80. PMID: 2147289
1989
Kiss J, Schlumpf M, Balazs R. Selective retardation of the development of the basal forebrain cholinergic and pontine catecholaminergic nuclei in the brain of trisomy 16 mouse, an animal model of Down's syndrome. Brain Res Dev Brain Res. 1989 Dec 1;50(2):251-64. PMID: 2575464
O'Hara BF, Fisher S, Oster-Granite ML, Gearhart JD, Reeves RH. Developmental expression of the amyloid precursor protein, growth-associated protein 43, and somatostatin in normal and trisomy 16 mice. Brain Res Dev Brain Res. 1989 Oct 1;49(2):300-4. PMID: 2572360
1987
Bacchus C, Sterz H, Buselmaier W, Sahai S, Winking H. Genesis and systematization of cardiovascular anomalies and analysis of skeletal malformations in murine trisomy 16 and 19. Two animal models for human trisomies. Hum Genet. 1987 Sep;77(1):12-22. PMID: 3623558
Reeves RH, Robakis NK, Oster-Granite ML, Wisniewski HM, Coyle JT, Gearhart JD. Genetic linkage in the mouse of genes involved in Down syndrome and Alzheimer's disease in man. Brain Res. 1987 Sep;388(3):215-21. PMID: 2960420
1986
Gearhart JD, Singer HS, Moran TH, Tiemeyer M, Oster-Granite ML, Coyle JT. Mouse chimeras composed of trisomy 16 and normal (2N) cells: preliminary studies. Brain Res Bull. 1986 Jun;16(6):815-24. PMID: 2875771
Reeves RH, Gearhart JD, Littlefield JW. Genetic basis for a mouse model of Down syndrome. Brain Res Bull. 1986 Jun;16(6):803-14. Review. PMID: 2944567
1985
Reed WD, Ozand PT. Adrenergic sensitivity of cultured murine trisomy 16 cells. Dev Pharmacol Ther. 1985;8(3):200-8. PMID: 2861071
1984
Ozand PT, Hawkins RL, Collins RM Jr, Reed WD, Baab PJ, Oster-Granite ML. Neurochemical changes in murine trisomy 16: delay in cholinergic and catecholaminergic systems. J Neurochem. 1984 Aug;43(2):401-8. PMID: 6145755
Singer HS, Tiemeyer M, Hedreen JC, Gearhart J, Coyle JT. Morphologic and neurochemical studies of embryonic brain development in murine trisomy 16. Brain Res. 1984 Aug;317(2):155-66. PMID: 6148129
This Resource is supported by NICHD/NIH contract #N01-HD-73265.
